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The potential of Novartis' Kymriah and Gilead's Yescarta fueled blockbuster projections from analysts and a flurry of industry interest in CAR-T development. But large price tags ($373,000 - $475,000), manufacturing challenges, and serious side effects have stymied wide-scale utilization of the therapies.
Why have these promising drugs under-performed, and what is the future of CAR-T?
Best Practices, LLC conducted an extensive research project to examine the genesis, launch and market struggles of these ground-breaking therapies. "CAR-T & Cell Therapy Products: Next generation of oncology products create chance for boom or bust" is a new 78-page case study that examines:
· CAR-T's pathway to the marketplace
· Kymriah's and Yescarta's market entry strategies…and slow launch curves
· The manufacturing and pricing challenges facing CAR-T therapies
· Why payers and pharma need to find reimbursement common ground
· What the future holds for next generation CAR-T therapies and pharma
Novartis and Gilead each took billon-dollar gambles with CAR-T, and now face heavy headwinds from payers that have hit the pause button to figure out how to afford $400,000 products. But the possibilities of CAR-T as a powerful weapon against other cancers has attracted an unprecedented wave of new T-cell therapy companies - as well as Top 10 pharma companies - that are investing heavily in next generation CAR-T products.
This study pulls together multiple sources of information across key issues affecting CAR-T development and launch to give new product development leaders critical insights into the potential and challenges facing CAR-T development and launch.
The report was based on extensive secondary research that involved dozens of industry, media, company and government reports and regulatory filings.
Select key insights uncovered from this report are noted below. Detailed findings are available in the full report.
Kymriah and Yescarta Market Entry Timelines 19
Kymriah and Yescarta Target Patient Groups 22
Launch Curves Slow for Kymriah and Yescarta 26
Kymriah and Yescarta Projected Sales and Consensus Estimates 27
Manufacturing Turnaround Challenges for Kymriah and Yescarta 34
Type of Treatment Centers Favored by Novartis and Gilead 23
Kymriah and Yescarta Market Entry Price Tags 49
ICER Analysis of Cost Effectiveness for Kymriah and Yescarta 57