Case Study: How Horizon Therapeutics Created an Ophthalmic Blockbuster in a Rare Disease Autoimmune Area for Thyroid Eye Disease

Best Practices, LLC presents a detailed case study that explores the winning strategies and approaches that have propelled this ophthalmic blockbuster in the rare disease autoimmune area of thyroid eye disease. This in-depth analysis highlights the education campaigns, patient support initiatives, innovative partnerships, and competitive resourcing implemented by Horizon Therapeutics to provide valuable lessons for industry stakeholders. Launch leaders will gain actionable insights from our comprehensive case study to shape their own success stories.

KEY TOPICS

• Introduction to Horizon Therapeutics And Tepezza For TED
• Tepezza’s Progression Since Launch
• Disease Awareness, Patient Education, and Symptom Identification
• Patient Access & Support Help TED Patients Navigate Authorization, et. al.
• D2C Education & Communications: A Cornerstone Of Tepezza’s Education Campaign
• Roadblocks And Resolutions In Tepezza’s Journey
• Partnerships: Tepezza Leveraged Strengths Of Partners To Enter Market
• Financial Health Of Horizon Since The Release Of Tepezza
• Tepezza Staffing Analysis: Examining the Talent to Compete in the TED Market
• Summary Lessons Learned From Tepezza’s Successful Market Entry

• Tepezza’s efficacy
• Tepezza’s unit cost per dose analysis
• Blockbuster sales curve
• Average number of Tepezza sales representatives and average number of targeted physicians
• Horizon Therapeutics’ operating margin, return on research capital, and net income margin compared to industry averages
• Horizon Therapeutics’ quick ratio, debt ratio, and return on equity compared to industry averages
• Average number of sales FTEs, MSLs, Patient Access Liaisons in the US market
• FTE ratio for Tepezza
• Geographic distribution of Tepezza FTEs

• Blockbuster Sales Curve: Tepezza's sales growth shows the rapid uptake of a blockbuster passing the $1 billion milestone 18 months post launch.
• Patient Support Program: Horizon has introduced Patient Access Liaisons who team up with patients and their HCPs to support them throughout the treatment process, including providing assistance with payers.

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